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國立陽明交通大學生物科技學系

Department of Biological Science and Technology, National Yang Ming Chiao Tung University
新竹市博愛街75號賢齊樓537室(辦公室),540室(實驗室)

R537 (O), R540 (L), Bio-ICT building, 75, Po-Ai Street, Hsinchu, Taiwan, 30068, ROC.

電話: 03-5731633 (辦公室); 03-5712121 ext 56959 (實驗室)

TEL: +886-3-5731633 (Office); +886-3-5712121 ext 56959 (Lab)

E-mail: ccchang01@nycu.edu.tw

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Sonodynamic therapy

Sonodynamic therapy

ROS-generating alginate-coated gold nanorods as biocompatible nanosonosensitisers for effective sonodynamic therapy of cancer

Ultrasonics Sonochemistry (2023) 96, 106437 (IF 9.336, Rank 1/32, Top 3%, Acoustic)

2021 Future Tech Award

2021 Future Tech Award

Virus sensing and anti-infection molecules screening biosensing platform development by palladium nano-thin-film electrochemical spectroscopy

Flexible nano thin film electrode development for biosensing

Flexible nano thin film electrode development for biosensing

  1. Chang C.-Y., et al., , Appl. Phys. Lett. (2019) 114, 093702 (IF: 3.791; Ranking 47/160, Physics, Applied)
  2. Chang C.-Y., et al., (2019) Inorganic Chemistry Communication, 107, 107461. (IF: 2.495; Ranking 21/45, Chemistry, Inorganic & Nuclear)

Nanodiamonds enhanced genome editing efficiency of CRISPR/Cas 9 system

Nanodiamonds enhanced genome editing efficiency of CRISPR/Cas 9 system

Carboxylate d nanodiamond-me diate d CRISPR-Cas9 delivery of human retinoschisis mutation into human iPSCs and mouse retina (2020) Acta Biomaterialia 101, 484-494. (IF=8.947, Rank=10/90, Top=11%)

Anti-SARS CoV2 infection drugs screening sensors

Anti-SARS CoV2 infection drugs screening sensors

Kiew L.V. et al., Development of flexible electrochemical impedance spectroscopy-based biosensing platform for rapid screening of SARS-CoV-2 inhibitors (2021) Biosensors & Bioelectronics 183, 113213 (IF=10.618, Rank=3/83, Chemistry Analytical)

Ni-DNA devices possesses memcapacitor and memristor properties

Ni-DNA devices possesses memcapacitor and memristor properties

Chu H.L. et al., Exploration and Characterization of the Memcapacitor and Memristor Properties of Ni-DNA Nanowire Devices (2017) NPG Asia Materials9, e430. (SCI IF:10.481; Ranking 37/335, Materials Science, Multidisciplinary)

Theranostics nanoparticle development for highly effective combination cancer therapy

Theranostics nanoparticle development for highly effective combination cancer therapy

Zhang J.F. et al., (2015) ACS Nano (SCI IF: 15.881; Ranking 21/335; Materials Science, Multidisciplinary).

Ni-DNA nanowire can be used in novel multi-state memory

Ni-DNA nanowire can be used in novel multi-state memory

 Programmable redox state of nickel ion chain in DNA, (2014) Nano Letters 14, 1026-1031. (SCI IF: 11.238; 5 year IF: 12.727; Ranking 11/155, Physics, Applied; citation 16)

Single domain antibody development

Single domain antibody development

Cheng T.-M. et al, Single domain antibody against carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) inhibits proliferation, migration, invasion and angiogenesis of pancreatic cancer cells, Eur. J. Cancer (2014) 50, 713-721. (IF: 9.162, Ranking 33/242, Oncology)

Drug delivery system development

Drug delivery system development

Nano-particles can be used as nanocarriers to improve the delivery and efficacy of antimetastatic agents is less explored when compared to cytotoxic agents.

  1. Fong S.S. et al., Chitosan-coated-PLGA nanoparticles enhance the antitumor and antimigration activity of Stattic – a STAT3 dimerization blocker, (2022) International Journal of Nanomedicine 17, 137-150 (IF 7.033, Rank 32/279, Top 10%, Pharmacology & Pharmacy, Citation 4)

Native LDL can be used as anti-cancer drug delivery system

1. Chu H.-L. et al., Synthesis of apolipoprotein B lipoparticles to deliver hydrophobic/amphiphilic materials. ACS Appl. Mater. Interfaces.  (2013) 5, 7509-7516. ( IF: 10.383, Ranking 49/345, Materials Science, Multidisciplinary)

2. Yang C.-L., et al., Local ablation of gastric cancer by reconstituted apolipoprotein B lipoparticles carrying epigenetic drugs (2021) Nanomedicine: Nanotechnology, Biology and Medicine, 37, 102450 (IF=6.458, Rank=28/140, Top 20 %, Medicine, Research & experimental)

Single EV71 virus detection platform development

Single EV71 virus detection platform development

Single EV71 virus detection platform development/ 腸病毒單一分子感測平台開發 (Nanotechnology, 2013; IF: 3.440)

Research hilights

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